Dibenz(c,f)azonines



United States Patent 3,498,988 DIBENZ[c,f]AZON[NES William J. Houlihan, Mountain Lakes, and Robert E.

Manning, Parsippany, N.J., assignors to Sandoz- Wander, Inc., Hanover N .J a corporation of Delaware No Drawing. Filed Mar. 15, 1967, Ser. No. 623,239 Int. Cl. C07d 35/28, 57/04; A61k 27/00 US. Cl. 260-289 1 Claim ABSTRACT OF THE DISCLOSURE The compounds and certain intermediates are useful as central nervous system stimulants and anti-inflammatories. They are prepared by converting an isoindolo[1,2-a]isoquinoline to its quaternary ammonium salt by treatment with a lower alkyl halide, e.g. methyl iodide, and reducing the salt by sodium in liquid ammonia to cleave the bond common to the five membered ring of the isoindolo moiety and six membered ring to the isoquinolino moiety, thus forming the nine membered N- heterocyclic ring of dibenz[c,f]azonine. For example, 2,3- dimethoxy 7 methyl 5,6,7,8 tetrahydrodibenz[c,f] azonine can thus be prepared from 2,3-dimethoxy- ,6,8, 1 Zb-tetrahydroisoindolo 1,2-a] isoquinoline.

This invention relates to compounds of the following formulae:

having a melting point of 57 to 58.5 C.;

R l l R N Ar(CH2) wherein n, Ar, R and R are as defined below;

R W R N (III) wherein R R and R are as defined below;

a q R i 3,498,988 Patented Mar. 3, 1970 R and R are independently either a hydrogen atom; a linear alkyl group having from one to four carbon atoms; or a linear alkoxyl group having from one to four carbon atoms;

or R and R may be joined to form a methylenedioxyl radical;

Ar is a radical having the formula:

wherein A A and A is independently a hydrogen atom; a fluorine atom; a chlorine atom; a linear alkyl group having from one to four carbon atoms, e.g. methyl; or a linear alkoxyl group, having from one to four carbon atoms; or taken together with its adjacent counterpart, a methylenedioxyl group (-OCH O-) R is a hydrogen atom; Ar or AICHz--, (as defined above);

Q is a linear alkyl group having from one to four carbon atoms;

Ring A is an ortho-phenylene group, an ortho-cyclohexyh ene group or an ortho-3-(cyclohexen)ylene radical; Z is a hydrogen atom; a linear alkyl group having from one to four carbon atoms; an allyl group; a crotonyl group or an organic radical having the formula:

wherein Compounds 11 include compounds of the classes of compounds 11a and III):

11 q zJ l N Ar-CH:

IIa

IIb

v1 GHaO q CHaO /N i r V 3 wherein R R and Ar are as defined above.

Compounds III include compounds of the classes of compounds IIIa, IIIb and H:

l ZWW H A! l IIIa IIIb AT-CHZ l wherein R R and Ar are as defined above.

Compounds TV include compounds of the classes of IVa IVb IVc wherein R, R and Ar are as defined above.

Compounds I, Ila, IIb, and V may be prepared according to reaction schemes A, B, C and D presented below. In the reaction schemes R R R Ar, Ring A, Z and Q are as defined above, and Y is a lower hydrocarbon group, e.g. an allyl group;

a crotonyl group; or a linear alkyl group having from one to four carbon atoms, or R and X is a chlorine atom; a bromine atom; or an iodine atom.

Compounds 111a and War; compounds H11; and IVb and compounds 111C and IVc may also be prepared by procedures similar to reaction schemes A, B and C respectively, as is hereinafter described.

Reaction Scheme A Q1130 q 0 0 L VII C aO

CH O

3 N 0 C 30f VIII:'1

CHaO

Reaction Scheme B i R C COOH a He XI q a R" O b R o y) W N 0 Ar A! l XII X123 Ila R action Scheme C 0 R1 O=/ O VIa. VIIa I XIV N +Ar-CHz-Mg halide VIII:2

Rl R; R2 l 01 i nofl H i Ar-OH2 II I XIIIzZ XIIIS According to reaction scheme A for the preparation of Compound I, Step a is a condensation reaction which may be effected by heating VI, i.e. 3,4-dimethoxyphenylethylamine, and VH, i.e. cis-1,2-cyclohexane dicarboxylic acid anhydride, in a solvent, e.g. refluxing in ortho-dichlorobenzene, to form the imide (VIIIzl), i.e. 2[2-(3,4- dimethoxyphenyl)ethyl]2,3,3a,4,5,6,7,7a-octahydro lHe isoindo1o-1,.3-clione.

Step b is a reduction of VIII:1 to the hydroxy amide (IX), i.e. 2-[2-(3,4-dimethoxyphenyl)ethyl]-1-hydroxy- 2,3,3a,4,5,6,7,7a-octahydro-lH-isoindol 3 one, e.g. by treatment with sodium borohydride (NaBH in methanol at room temperature, i.e. 20 C.

Step c is a cyclization of IX by heating in the presence of a strong acid, e.g. refluxing with concentrated hydrochloric acid in methanol, to the lactam (X21), i.e. 2,3- dimethoxy 5,6,8,8a,9,10,ll,12,12a,12b decahydro 8- oxo-isoindolo l,2-a]isoquinoline.

Step at is a reduction of Xzl to Compound I, e.g. by refluxing with lithium aluminum hydride (LAH) in diethyl ether (ether).

According to reaction scheme B, for the preparation of a compound Ila, Step a is a condensation, which may be effected by heating (VIa), e.g. phenylethylamine, with XI, e.g. ortho-benzoyl hexahydrobenzoic acid, in the presence of an acid, i.e. heating a small amount of p-toluenesulfonic acid in toluene, to form the intermediate XII.

Step b is a cyclization of compound XII which may be effected by heating in the presence of a strong acid, e.g. heating with concentrated hydrochloric acid in methanol, to give the lactam (Xz2a) related to compound IIa.

In Step 0 X:2a is reduced to compound IIa, e.g. by heating with borane in tetrahydrofuran (THF) or with LAH in ether.

According to reaction scheme C for the preparation of a compound IIb, Step a is a condensation of compound VIa, e.g. phenylethylamine, with IIIa, cisor trans-1,2- cyclohexane dicarboxylic acid anhydride; it may be carried out as described in step a of reaction scheme A.

Step b is a condensation of the phthalimide (VIII22) with a benzyl-radical-containing Grignard reagent. Such a Grignard reagent may be prepared by well known methods. The condensation may be eifected by adding the Grignard reagent dropwise to compound VIIIzZ in a solvent, e.g. THP, with agitation and agitating the mixture at room temperature for a suitable period of time, e.g. from 4 to 24 hours, to form the intermediate XIII:2.

Step 0 is a two-stage cyclization which may be effected by heating compound XIII:2 in the presence of a strong acid, e.g. refluxing with concentrated hydrochloric acid in methanol, to give the dehydrated amide XIII:3 which then cyclizes to the lactam (X22b).

Step a' is a reduction. The lactam (X12b) is reduced to the compound IIb, e.g., by the method described in Step 0 of reaction scheme B.

Reaction scheme B is preferred for the preparation of compounds Ila, which compounds have a phenyl radical. However, compounds Ila can also be prepared by the procedure of reaction scheme C by using a phenyl-radicalcontaining Grignard reagent (XIV). Similarly, while reaction scheme C is preferred for the preparation of compounds Ilb, which compounds have a benzyl radical, said compounds may also be obtained by the procedure of reaction scheme B by using an o-(benzylcarbonyl)hexahydrobenzoic acid wherein Ar is as defined above; in place of compound XI.

In the preparation of compound IIa by reaction scheme B, if one starts with phenylethylamine (as VIa) and ortho-benzoylhexahydrobenzoic acid (as XI), 12b-phenyl, 5,6,8,8a,9,12,l2a,12b octahydroisoindolo [l,2a]isoquinoline is obtained as the compound IIa. When a compound VIa is used wherein R and R each are a linear alkoxyl group, e.g. methoxy, ethoxy, propoxy or butoxy, the corresponding compound 11a is obtained, i.e. wherein R and R each are a linear alkoxy group. Similarly, if a compound VIa is used wherein R and R each are a linear alkyl group, e.g. methyl ethyl, propyl and butyl, the corresponding compound 11a is obtained, i.e. wherein R and R each are a linear alkyl group.

If a methylenedioxy-containing phenylethylamine is used, the corresponding compound 11a is obtained, i.e. wherein R and R are joined to form methylenedioxy.

Similarly, in the preparation of compound Ila, if in place of ortho-benzoylhexahydrobenzoic acid, i.e. compound XI wherein each of A A and A is a hydrogen atom, one uses, e.g. ortho-(p-chlorobenzoyl)-hexahydrobenzoiz acid, the corresponding compound Ila is obtained, i.e. wherein A and A are hydrogen atoms and A is chloro. Similarly, if one uses as XI a compound wherein any of A A or A is butyl, chloro or fluoro, the corresponding compound 11a is obtained. If ortho-(p-methoxybenzoyl)hexahydrobenzoic acid, i.e. a compound XI wherein A is methoxy, i.e. a lower alkoxy and each of A and A is a hydrogen atom, the corresponding compound Ila is obtained. If ortho-(propylbenzoyl)hexahydrobenzoic acid is used, i.e. a compound XI wherein one of A A and A is a lower linear alkyl group, the corresponding compound IIa is obtained. If a methylenedioxycontaining ortho-benzoylhexahydrobenzoic acid is used as XI, the corresponding compound Ila is obtained.

Variation of the starting materials, discussed above with respect to the preparation of the corresponding compounds II, also applies to the preparation of compounds II and IV discussed below, as well as intermediates and derivatives thereof unless specifically noted.

Compounds IIIa may be obtained by following the general procedure of reaction scheme A, but replacing the 1,2-cis-cyclohexane dicarboxylic acid anhydride with 4- cyclohexene-1,2-dicarboxylic acid anhydride. Similarly, compounds IVa may be obtained by following the general procedure of reaction scheme A, but replacing the 1,2- cis-cyclohexane dicarboxylic anhydride with phthalic acid anhydride.

By selection of phenylethylamines having R and R as defined above, the corresponding compounds 111a and IVa may be obtained.

Following the general procedures of reaction schemes B or C, but using 4-cyclohexene-l,Z-dicarboxylic acid anhydride in place of the 1,2-cyclohexane dicarboxylic acid anhydride, the corresponding compound IIIb or IIIc, may be obtained.

Following the general procedure of reaction scheme B or C, but using phthalic acid anhydride in place of the 1,2-cyclohexane dicarboxylic acid anhydride, the corresponding compounds IVb or IVc, may be obtained. By selection of starting materials having the su'bstituents as defined above, the corresponding compounds III and IV may be obtained.

According to reaction scheme D for the preparation of compounds V, Step a is a conversion of a compound XV to the corresponding quaternary ammonium salt by treatment with QX, a lower alkyl halide, e.g. methyl iodide; preferably in a solvent, such as ether or ethanol.

Step b is a reduction. The reduction may be effected by the use of sodium in liquid ammonia.

Compounds XV include compounds I, II, III and IV and may be prepared according to reaction schemes A, B or C, whichever is appropriate. Compounds XV having a lower hydrocarbon group as Y substituent may be prepared according to the procedure of reaction scheme B by using the appropriate ortho-acylbenzoic acid for XI in Step a. Similarly, compounds XV having a lower hydrocarbon group as the Y substituent may also be prepared according to the procedure of reaction scheme C by using the appropriate lower hydrocarbon-group-containing Grignard reagent for X-IV in Step b.

It is also possible, according to reaction scheme D, to prepare compounds V from analogues of XV bearing halogen atoms, e.g. fluorine, chlorine or bromine atoms; the halogen atoms being replaced by hydrogen atoms during the reduction (Step 11) to give the corresponding compound V bearing hydrogen in place of the halogen atoms. It is preferred, however, to use halogen-free compounds XV related to the desired compound V.

The reaction schemes A, B and C may be varied to obtain the desired compounds and intermediates of this invention, however, borane should not be used in carrying out the reductions of carbonyl-group-containing intermediates of compounds III or any other compounds of this invention which also have ethylenically unsaturated double bonds, e.g. allyl groups, as its use'leads to reaction at double bonds as Well as carbonyl groups. For example, this could lead to the conversion of a compound III to a compound II. LAH, however, may be used in such instances.

Compounds I, III, and V and their pharmaceutically acceptable acid addition and quaternary ammonium salts are central nervous system (CNS) active compounds. They are useful, e.g. as CNS stimulants, hypotensives and anti-infiamrnatories. They are administered to mammals either orally or parenterally in daily doses of from 0.5 to mg./kg. of body weight, e.g. from 30 to 600 milligrams per diem, preferably administered in divided doses from 2 to 4 times a day; a single daily oral dose of up to 200 milligrams is also acceptable.

The acid addition and quaternary ammonium salts of compounds I, III, and V are prepared according to well known procedures from compounds I, III, and V, respectively. They are all useful, in accord with recognized procedures, for the preparation of corresponding pharmaceutically acceptable salts.

Among the pharmaceutically acceptable acid addition salts are salts of organic acids, e.g. tartaric acid; inorganic acids, e.g. hydrochloric acid, hydrobromic acid and sulfuric acid; monobasic acids, e.g. an alkylsulfonic acid, such as methylsulfonic acid (H CSO H); dibasic acids, e.g. succinic acid; tribasic acids, e.g. phosphoric acid and citric acid; saturated acids, e.g. acetic acid; ethylenically unsaturated acids, e.g. maleic acid and fumaric acid; and aromatic acids, e.g. salicylic acid and arylsulfonic acids, such as phenylsulfonic acid. The only limitation on the acid is that the resulting salt be Pharmaceutically acceptable; it is preferred, however, that the acid addition salt be water-soluble.

Each of the pharmaceutically active compounds of this invention may be e.g. incorporated, for oral administration, in a tablet as the sole active ingredient. A typical tablet is constituted by from 1 to 3 percent binder, e.g. tragacanth; from 3 to 10 percent disintegrating agent, e.g. corn starch; from 2 to 10 percent lubricant, e.g. talcum; from 0.25 to 1.0 percent lubricant, e.g. magnesium stearate; an average dosage of active ingredients; and q.s. 100 percent of filler, e.g. lactose; all percentages being by Weight. Tablets are prepared according to standard tabletting techniques, which are well-known in the art, employing the necessary amounts of conventional granulating liquids, e.g. alcohol SD-30 and purified water. An exemplary tabletting formulation for the instant active compounds is:

Parts Title Compound of Example 1 30 Tragacanth 2 Lactose -s 59.5 Corn starch 5 Talcum 3 Magnesium Stearate 0.5 Alcohol SR-30, purified water Q.s.

'Examples illustrative of this invention follow. In the examples all temperatures are centigrade and all percents and parts are by weight, unless specified otherwise. Parts by weight are related to parts by volume as a kilogram is rela ed to a liter.

8 EXAMPLE 1 2,3-dimethoxy-5,6,8,8a,9,10,1 1, l2, l2a,l2b-decahydroisoindolo[1,2-a]isoquinoline CHaO (a) Preparation of 2-[2-(3,4-dimethoxyphenyl)ethyl]- 2,3,3a,4,5,6,7,7a-octahydro-lH-isoindoll,3-dione omoq cnso N A solution of 90.5 parts of 3,4-dimethoxyphenylethylamine and 77 parts of cis-1,2-cyclohexanedicarboxylic anhydride in 100 parts by volume of ortho-dichlorobenzone is refluxed under a water separator for 3 hours, then allowed to cool and stand at room temperature for 16 hours. Crystals formed are collected as 118 parts of compound (a), melting point (M.P.) to 88 C.

(b) Preparation of 2-[2-(3,4-dimethoxyphenyl)ethyl] -1- hydroxy-Z,3,3a,4,5,6,7,7a-octahydro-1H-isoindol-3-one OH O- Twenty parts of compound (a) are suspending with stirring in 150 parts by volume of methanol cooled in a water bath at room temperature. 3.9 parts of sodium borohydride (NaBH in 50 parts by volume of methanol is added in two portions over 5 minutes. The mixture is allowed to stand for 35 minutes and then diluted with water to 800 parts by volume. The mixture is then cooled for 15 minutes in an ice bath and filtered, yielding crude compound (b); on recrystallization from methanol-ether, compound (b), M.P. 136 to 138 C., is obtained.

(c) Preparation of 2,3-dimethoxy-5,6,8,8a,9,l0,ll,12,12a, 1Zb-decahydro-S-oxo-isoindolo{l,2-a]isoquinoline CHaO Eleven parts of compound (b) in parts by volume of methanol and 3 parts by volume of concentrated hydrochloric acid are heated under reflux for 2 hours. The mixture is then cooled, concentrated under vacuum, di-

9 luted with Water and extracted with ether. The ether phase is dried over sodium sulfate and evaporated under vacuum. The residue is crystallized from ether to give 7 parts of compound (c), M.P. 112 to 114 C.

((1) Preparation of 2,3-dimethoxy-5,6,8,8a,9,10,11,12,12a, 12b-decahydroisoindolo [1,2-a] isoquinoline EXAMPLE 2 9,10-dimeLhoxy-3-methyl-5,6-tetramethylene-1H-2,3,4,5, 6,7-hexahydro-3-benzazonine hydrochloride we lew.

CHitO l '11 01 This example illustrates the preparation of a Compound V by a procedure according to reaction scheme D, described above.

(a) Preparation of 2,3-dimethoxy-5,6,8,8a,9,10,11,12,12a, IZb-decahydroisoindolo 1,2-a] isoquinoline methiodide A solution of 4 parts of 2,3-dimethoxy-5,6,8,8a,9,10,- 1l,12,12a,IZb-decahydroisoindolo[l,2-a]isoquinoline in 4 parts by volume of ethanol and 25 parts by volume of ether and 7 parts by volume of methyl iodide is allowed to stand at room temperature about 16 hours yielding 4 parts of the corresponding methiodide, i.e. compound (a).

(b) Preparation of 9,10,dimethoxy-3-methy1-5,6-tetramethylene-1H-2,3,4,5,6,7-hexahydro-3-benzazonine hydrochloride 6.5 parts of sodium is added to 26 parts of compound (a) in 500 parts of liquid ammonia cooling in a solid carbon dioxide-acetone bath. After stirring for 1 hour the solution is allowed to evaporate for 16 hours. The residue is mixed with water and chloroform. The chloroform layer is dried over sodium sulfate and evaporated under vacuum. The residue is converted to the hydrochloride and crystallized from ethanol-ether to give 10 parts of the title compound, M.P. 230 to 232 C.

Replacing the methyl iodide of this example with ethyl bromide results in the preparation, in a similar manner, of the corresponding compound V, i.e. 9,10- dimethoxy 3 ethyl-5,6-tetramethylene-1H-2,3,4,5,6,7- hexahydro-3-benzazonine.

10 EXAMPLE 3 2,3-dimethoxy-5,6,8,8a,9,12,12a,12b-octahydroisoindolo- [1,2-a] isoquinoline onao q OHaO YN This example illustrates the preparation of 2,3-dimethoxy 5,6,8,8a,9,12,12a,12b-octahydroisoindolo[1,2-a] isoquinoline which is a compound IIIa, by a process similar to that described in Example 1. This compound may be used for the preparation of the corresponding compound V, i.e. 9,10-dimethoxy-3-methyl-5,6-butenylene-11-1-2,3,4,5,6,7-hexahydro-3-benzazonine, as illustrated in Example 4.

(21) Preparation of 2- [2- 3 ,4-dimethoxyphenyl ethyl] 2,3,3a, 4,7,7a-hexahydro-1H-isoindol-1,3-dione A solution of 18.1 parts of 3,4-dimethoxyphenylethylamine and 15.2 parts of cis-4-cyclohexene-1,2-dicarboxylic acid anhydride in 20 parts by volume of ortho-dichlorobenzene is heated under reflux for 3 hours. The reaction mixture is cooled and diluted with parts by volume of ether. Thirty-one parts of compound (a), having a melting point of 107 to 109 C., are recovered from the reaction mixture.

(b) Preparation of 2-[2-(3,4-dimethoxyphenyl)ethyl]-1- hydroxy-2,3,3a,4,7,7a-hexahydro-lH-isoindol-S-one In a vessel 20 parts of compound (a) are suspended in parts by volume of methanol with stirring in a water bath at room temperature. Four parts of sodium borohydride (NaBH in 50 parts by volume of methanol are added and the mixture stirred for 40 minutes. The mixture is then diluted with 150 parts by volume of water and cooled yielding 15 parts of compound (b) as crystals, M.P. 134 to 136 C.

(c) Preparation of 2,3-dimethoxy-8-oxo-5,6,8,8a,9,12, 12a,12b-octahydroisoindolo 1,2-a1isoquino1ine CH OQ W I t Q Thirteen parts of compound (b) are refluxed for 2 hours in 15 0 parts by volume of methanol and 5 parts by volume of concentrated hydrochloric acid. The reaction mixture is concentrated under vacuum, diluted with aqueous sodium carbonate solution, then extracted with methylene chloride. The organic extract is dried over sodium sulfate and then evaporated yielding a residue which on crystallization from ether gives 9 parts of compound (c), M.P. 89 to 92 C.

(d) Preparation of 2,3-dimethoxy-5,6,8,8a,9,12,12a,l2boctahydroisoindolo[ 1,2-a] isoquinoline Thirty-seven parts of compound is placed in a Soxhelet extractor over a flask containing 21 parts of LAH and 2,100 parts of ether and the mixture refluxed for 16 hours. Thirty-five parts of the title compound are obtained as a syrup which slowly crystallizes on standing, M.P. 72 to 74 C.

Replacing the 3,4-dimethoxyphenylethylamine with 4- methoxyphenylethylamine results in the preparation, in a similar manner, of the corresponding compound Illa, i.e. 2-methoxy-5,6,8,8a,9,12,12a,1Zb-octahydroisoindolo- [1,2-a] isoquinoline.

EXAMPLE 4 9-10-dimethoxy-3-methyl-5,6-butenylene-1H-2,3,4,5,6,7- hexahydro-3-benzazonine hydrochloride This example illustrates the preparation of 9,10-dimethoxy-S-methyl 5,6 butenylene-1H-2,3,4,5,6,7-hexa hydro-3-benzazonine which is a compound V, by a process similar to that described in Example 2.

Twenty-five parts of 2,3-dimethoxy-5,6,8,8a,9,12,12a, 12b-octahydroisoindolo[l,2-a]isoquinoline is dissolved in 70 parts by volume of ethanol and 40 parts by volume methyl iodide and the solution allowed to stand for several hours. Thirty-two parts of the corresponding methiodide is collected as crystals from the solution.

2.6 parts of sodium is added to a suspension of 25 parts of the methiodide in liquid ammonia with stirring while cooling in a solid carbon dioxide-acetone bath. After stirring for one hour the mixture is allowed to evaporate for 16 hours. The residue is mixed with water and chloroform. The chloroform layer is dried over sodium sulfate and evaporated under vacuum. The residue is converted to the hydrochloride and crystallized from an ethanol-benzene-ether solution to give 9 parts of the title compounds, M.P. 155 to 159 C.

Following the procedure described in this example but using ethyl iodide in place of the methyl iodide the corresponding compound V is obtained, i.e. 9,10-dimethoxy- 3 ethyl 5,6 butenylene-1H-2,3,4,5,6,7-hexahydro-3- benzazonine.

EXAMPLE 5 2,3 -dimethoxy-5,6,8,1 Zb-tetrahydroisoindolo 1,2-a] isoquinoline hydrochloride CHaO This example illustrates the preparation of 2,3-dimethoxy-5,6,8, 1 Zb-tetrahydroisoindolo 1,2-a] isoquinoline which is a compound IVa, may be used as an intermediate for the preparation of 2,3-dimethoxy-7-methyl 5,6,7,8- tetrahydrodibenz[c,f] azonine, which is a compound V, as described in Example 6.

1 2 (a) Preparation of 2[2-(3,4-dirnethoxyphenyl)ethyl] phthalimide O A solution of 108 parts of 3,4-dimethoxyphenylethylamine and 86 parts of phthalic anhydride in 200 parts by volume of ortho-dichlorobenzene is heated under reflux for 3 hours. After cooling, the solid product is collected by filtration and recrystallized from chloroformmethanol yielding parts of compound (a), M.P. 169 to C.

(b) Preparation of 2[2-(3,4-dimethoxyphenyl)ethyl]-1- hydroxy-2,3-dihydro-1H-isoindol-3-one The filtrate is diluted with water yielding 7.5 parts of compound (b), M.P. 138 to 140 C.

(0) Preparation of 2,3-dimethoxy-8-oxo-5,6,8,lZb-tetrahydroisoindolo[ l ,2,-a] isoquinoline CHaO CHsO

CHsO- CHaO One part of compound (b) in 10 parts by volume of methanol and 0.3 part by volume of concentrated hydrochloric acid are refluxed for one hour. The mixture is then diluted with water, yielding 0.9 part of crystals of compound (c), M.P. 166 to 168 C.

(d) Preparation of 2,3-dimethoxy-5,6,8,lZb-tetrahydroisoindolo 1,2-a] isoquinoline hydrochloride A slurry of 75 parts of compound (c) in 2,000 parts by volume of tetrahydrofuran (THF) is added dropwise over 15 minutes to 1,010 parts by volume of a one molar THF solution of borane with stirring under nitrogen. After stirring for one half hour, the mixture is refluxed for 7 hours. With cooling, 300 parts by volume of 6 normal hydrochloric acid is added and the mixture refluxed for 2 hours. The mixture is then concentrated under vacuum to 400 parts by volume. The concentrate is treated with 600 parts by volume of a 6 normal sodium hydroxide solution and extracted with methylene chloride. The methylene chloride solution is dried over sodium sulfate and evaporated. The residue is converted to the hydrochloride and crystallized from methanol, yielding 37 parts of the title compound which melted with decomposition at 244 C.

Following the procedure described in this example, but using 3-methoxy-4-methylphenylethylamine in place of EXAMPLE 6 2,3-dimethoxy-7-methyl-5,6,7,8-tetrahydrodibenz [c,f]azonine This example illustrates the preparation of 2,3-dimethoxy-7-methyl-5,6,7,8 tetrahydrodibenz[c,f]azonine, i.e. a compound V, by a process similar to that described in Example 2.

A solution of 32 parts of 2,3-dimethoxy-5,6,8-12b-tetrahydroisoindolo[1,2-a]isoquinoline in 85 parts by volume of methyl iodide, 35 parts by volume of ethanol and 175 parts by volume of ether is allowed to stand at room temperature for several hours, yielding 45 parts of the corresponding methiodide.

Eleven parts of sodium are added to 45 parts of the methiodide suspended in 700 parts by volume of liquid ammonia with stirring cooled in a solid carbon dioxideacetone bath. After stirring for one hour the mixture is allowed to evaporate for 16 hours. The crude residue is crystallized twice from methanol to give 7 parts of the title compound, M.P. 102 to 104 C.

Following the procedure described in this example but using propyl iodide in place of the methyl iodide the corresponding compound V is obtained.

EXAMPLE 7 2,34limethoxy-12b-phenyl-5,6,8,12b-tetrahydroisoindolo 1,2-a] isoquinoline omo- This example illustrates the preparation of 2,3-dimethoxy 12b-phenyl 5,6,8,12b tetrahydroisoindolo [1,2-a1isoquinoline, which is a compound IVb by following a procedure according to reaction scheme B described above. The title compound may be used to prepared the corresponding compound V, as illustrated by Example 8.

(a) Preparation of 2,3-dimethoxy-12b-phenyl-8-oxo-5,6, 8,IZb-tetrahydroisoindolo[1,2-a]isoquinoline A solution of 18.1 parts of 3,4-dimethoxy phenylethylamine and 22.6 parts of ortho-benzoylbenzoic acid and 0.25 part of p-toluene sulfonic acid in 300 parts by volume of toluene is heated under reflux for about 16 hours. The reaction mixture is concentrated under vacuum and the residue dissolved in chloroform. The chloroform solution is washed with dilute aqueous sodium carbonate and water, dried over sodium sulfate and then evaporated yielding 25 parts of crude intermediate, 4 parts of which is then refluxed with 50 parts by volume of methanol and 1.5 parts by volume of hydrochloric acid for 4 hours. The mixture is then cooled and 3 parts of crystals of compound (a) are collected, M.P. 202 to 203 C.

(b) Preparation of 2,3-dimethoxy-l2b-phenyl-5,6,8,12btetrahydroisoindolo 1,2-a] isoquinoline A solution of 70 parts of compound (a) in 1,500 parts by volume of THE is added dropwise over 30 minutes to 750 parts by volume of stirred one molar THF solution of borane under nitrogen. The mixture is refluxed for 7 hours, cooled, 250 parts by volume of 6 normal hydrochloric acid added and the mixture refluxed for 2 hours. The mixture is then concentrated under vacuum and the residue is treated with 500 parts by volume of 6 normal sodium hydroxide solution, and then methylene chloride is added. The methylene chloride layer is dried over sodium sulfate and evaporated. The residue is crystallized from ether yielding 67 parts of the title compound, M.P. 172 to 174 C.

Following the procedure as described in this example, but using ortho-(para-chlorobenzoyl)benzoic acid in place of the ortho-benzoylbenzoic acid, the corresponding compound IVb is obtained.

EXAMPLE 8 2,3 -dimethoxy-7-methyl-13-phenyl-5,6,8 ,13 -tetrahydrodibenz [c,f azonine hydrochloride This example illustrates the preparation of a compound V from the corresponding compound IVb.

A solution of 6 parts and 15 parts by volume of methyl iodide, 25 parts by volume of ethanol and 25 parts by volume of methylene chloride is prepared and allowed to stand at room temperature for 16 hours. The solution is evaporated, the residue dissolved in acetone, and diluted with ether. Nine parts of the resultant methiodide are recovered as precipitate by filtration.

EXAMPLE 9 CHsO 12b-(p-chlorobenzyl) -2,3-dimethoxy-5,6,8,12b-tetrahydroisoindolo[1,2-a]isoquinoline omo- A CHaO This example illustrates the preparation of 12b-(pchlorobenzyl) 2,3-dimethoxy-5,6,8,IZb-tetrahydroisoindolo[1,2-a]isoquinoline, which is a compound IVc, according to reaction scheme C, as described above.

(a) Preparation of 12b-(p-chlorobenzyl)-2,3-dimethoxy- 8-oxo-5,6,8,12b-tetrahydroisoindolo[ 1,2-a] isoquinoline CHsO I A Grignard reagent is prepared from 2 parts of magnesium and 12 parts of p-chlorobenzyl chloride in 100 parts by volume of ether, and added dropwise to a stirred suspension of 15.5 parts of N-[2-(3,4-dimethoxyphenyl)- ethyl] phthalimide, (which may be prepared as described above in Example 5) in 200 parts by volume of THF. The mixture is stirred for 16 hours and then dilute ammonium hydroxide added. The organic layer is dried over sodium sulfate and evaporated to give a crystalline residue, which is then washed with a small amount of ether, yielding 16 parts of intermediate product. This intermediate product is heated under reflux for 16 hours in 300 parts by volume of methanol and parts by volume of concentrated hydrochloric acid. The mixture is then evaporated and the residue crystallized from methanol yielding 11 parts of compound .(a), M.P. 193 to 194 C.

(b) Preparation of 12b-(p-chlorobenzy1)-2,3-dimethoxy- 5,6,8,12b-tetrahydroisoindolo[ 1,2-a] isoquinoline A solution of 55 parts of compound (a) in 800 parts by volume of THF is added dropwise over minutes to a solution of 17 parts of LAH in 1,500 parts by volume of ether and heated under reflux for 20 hours. The mixture is then cooled and decomposed by the addition of water, the mixture is then filtered through Celite. The organic phase of the filtrate is dried and evaporated under vacuum and crystallized from ether to give 44 parts of the title compound, M.P. 126 to 127 C.

Following the general procedure described in this example, but using a Grignard reagent prepared from pmethoxybenzyl chloride in place of the p-chlorobenzyl chloride, the corresponding compound We is obtained.

EXAMPLE 1O 12b-benzyl-2,3-dimethoxy-5,6,8,IZb-tetrahydroisoindolo[ 1,2-a] isoquinoline 2,3 dimethoxy-5,6,8,12b-tetrahydroisoindolo [1,2-a]isoquinoline, which is a compound We.

(a) Preparation of 1Zb-benzyl-Z,3-dimethoxy-8-oxo-5,6,8, 12b-tetrahydroisoindolo 1,2-a] isoquinoline Following the procedure described above in Example 9, a Grignard reagent is prepared from 13.3 parts of magnesium and 95.2 parts of benzyl chloride in 800 parts by volume of ether, and reacted with 108 parts of 2-[2-(3,4- dimethoxyphenyl)ethyl] phthalimide suspended in 1,500 parts by volume of THF, yielding parts of intermediate product which is then heated under reflux in 2,000 parts by volume of methanol and parts by volume of concentrated hydrochloric acid for 20 hours. The reaction mixture is evaporated and the residue crystallized from methanol to give 90 parts of compound (a), MP. to

(b) Preparation of 12b-benzyl-2,3-dimethoxy-5,6,8,l2btetrahydroisoindolo 1,2-a] -isoquinoline Following the procedure described above in Example 9, a solution of 85 parts of compound (a) in 1,000 parts by volume of THF is mixed with 40 parts of LAH in 2,000 parts by volume of ether and the mixture refluxed 24 hours. The reaction mixture yields 53 parts of the title compound crystallized from ether, M.P. 130 to 131 C.

Replacement of the benzyl chloride with 3,4,5-trimethylbenzyl chloride results in the preparation, in a similar manner, of the corresponding compound IVc.

What is claimed is: 1. A compound which in its free base form is of the formula:

CI-IQDQ/W 01130 \/N said compound having a melting point of 57 to 5 8.5 C.

References Cited UNITED STATES PATENTS 3,015,661 l/1962 Georgian 260-289 ALEX MAZEL, Primary Examiner ANNE MARIE T. TIGHE, Assistant Examiner U.S. Cl. X.R. 

